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KMID : 0367320110220040287
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2011 Volume.22 No. 4 p.287 ~ p.293
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Polymorphisms of CDH9 and CDH10 in Chromosome 5p14 Associated with Autism in the Korean Population
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Lee Ae-Ri
Park Jung-Won
Nam Min
Bang Hee-Jung
Yang Jae-Won
Choi Kyung-Sik
Kim Su-Kang
Chung Joo-Ho
Kwack Kyu-Bum
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Abstract
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Objectives: The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population.
Methods: Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software.
Results: All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD.
Conclusion: Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.
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KEYWORD
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Autism Spectrum Disorder, CDH9, CDH10, 5p14, Association study, Polymorphism
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